This table is designed as a hypothesis testing, teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system.
The table contains lists of drugs in columns under the designation of specific cytochrome P450 isoforms. A drug appears in a column if there is published evidence that it is metabolized, at least in part, via that isoform. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug.
If you use this site in your work, please acknowledge it by citing the following reference:
Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). http://medicine.iupui.edu/clinpharm/ddis/table.aspx. Accessed [date].
The Manitoba Drug Benefits and Interchangeability Formulary lists therapeutically effective drugs of proven high quality that have been approved as eligible benefits under the Pharmacare drug benefit program. It also includes a list of interchangeable drugs. It is compiled with the recommendations of the Common Drug Review and the advice of the Manitoba Drug Standards and Therapeutics Committee, assisted by Manitoba Health staff. The Minister of Health gives the final approval for benefits under the Pharmacare drug benefit program
Search the Pharmacare Drug Benefits Formulary by Brand Name, Active Ingredient or Drug Identification Number (DIN). For more advanced search options, such as Therapeutic Classification, use the Advanced Search.
The Interim Federal Health Program (IFHP), funded by Citizenship and Immigration Canada (CIC), provides temporary health care coverage for the non-insured populations who are either awaiting an immigration decision, or who are resettling in Canada, in order to reduce risks to public health, ensure care for these populations and assist with their successful integration into Canadian society